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Phase Ib/II Trial of SX-682 in Combination With Nivolumab for Refractory RAS Mutated (RAS) Microsatellite Stable (MSS) Metastatic Colorectal Cancer (mCRC) (STOPTRAFFIC-1)

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Trial Profile

Phase Ib/II Trial of SX-682 in Combination With Nivolumab for Refractory RAS Mutated (RAS) Microsatellite Stable (MSS) Metastatic Colorectal Cancer (mCRC) (STOPTRAFFIC-1)

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 02 Feb 2026

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At a glance

  • Drugs Nivolumab (Primary) ; SX 682 (Primary)
  • Indications Adenocarcinoma; Colon cancer; Colorectal cancer; Rectal cancer
  • Focus Adverse reactions; Proof of concept
  • Acronyms STOPTRAFFIC-1

Most Recent Events

  • 22 Jan 2026 Planned End Date changed from 31 Jan 2026 to 31 Jul 2026.
  • 22 Jan 2026 Planned primary completion date changed from 31 Jan 2026 to 31 Jul 2026.
  • 05 Aug 2025 Status changed from recruiting to active, no longer recruiting.

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