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Phase I/II study of Pelareorep in combination with atezolizumab with or without chemotherapy in patients with advanced or metastatic GI tumors

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Trial Profile

Phase I/II study of Pelareorep in combination with atezolizumab with or without chemotherapy in patients with advanced or metastatic GI tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 30 Mar 2026

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At a glance

  • Drugs Atezolizumab (Primary) ; Pelareorep (Primary) ; Fluorouracil; Folinic acid; Gemcitabine; Irinotecan; Oxaliplatin; Paclitaxel; Tipiracil/trifluridine
  • Indications Adenocarcinoma; Anal cancer; Colorectal cancer; Gastrointestinal cancer; Pancreatic ductal carcinoma; Squamous cell cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms GOBLET

Most Recent Events

  • 19 Mar 2026 Results presented in the Oncolytics Biotech Media Release.
  • 19 Mar 2026 According to an Oncolytics Biotech media release, data from this study will be presented at the American Association for Cancer Research (AACR) Annual Meeting 2026, at the San Diego Convention Center from April 17-22, 2026.
  • 25 Feb 2026 According to an Oncolytics Biotech media release, the positive efficacy signal in GOBLET Cohort 4 has defined a clear registrational path for pelareorep in second-line and later squamous cell anal cancer. The company is focussed on registrational programs in anal and colorectal cancer, concluding enrollment in the GOBLET gastrointestinal study after generating sufficient data for FDA approval.

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