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Phase I/II study of Pelareorep in combination with atezolizumab with or without chemotherapy in patients with advanced or metastatic GI tumors

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Trial Profile

Phase I/II study of Pelareorep in combination with atezolizumab with or without chemotherapy in patients with advanced or metastatic GI tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 03 Nov 2025

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At a glance

  • Drugs Atezolizumab (Primary) ; Pelareorep (Primary) ; Fluorouracil; Folinic acid; Gemcitabine; Irinotecan; Oxaliplatin; Paclitaxel; Tipiracil/trifluridine
  • Indications Adenocarcinoma; Anal cancer; Colorectal cancer; Gastrointestinal cancer; Pancreatic ductal carcinoma; Squamous cell cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms GOBLET

Most Recent Events

  • 16 Sep 2025 According to an Oncolytics Biotech media release, The company anticipates providing a cohort 5 interim efficacy update, including overall survival, in the first quarter of 2026. And, expects to complete the cohort 5 enrolment by end of 2026
  • 16 Sep 2025 According to an Oncolytics Biotech media release, The company expects to complete the enrolment for cohort 4 and provide an efficacy update regarding ORR in cohort 4 in the fourth quarter of 2025.
  • 08 Sep 2025 Primary endpoint has been met. (efficacy based on objective response rate (ORR) and/or disease control rate assessed at week 16)

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