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Phase I/II study of Pelareorep in combination with atezolizumab with or without chemotherapy in patients with advanced or metastatic GI tumors

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Trial Profile

Phase I/II study of Pelareorep in combination with atezolizumab with or without chemotherapy in patients with advanced or metastatic GI tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 20 May 2025

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At a glance

  • Drugs Atezolizumab (Primary) ; Pelareorep (Primary) ; Fluorouracil; Folinic acid; Gemcitabine; Irinotecan; Oxaliplatin; Paclitaxel; Tipiracil/trifluridine
  • Indications Adenocarcinoma; Anal cancer; Colorectal cancer; Gastrointestinal cancer; Pancreatic ductal carcinoma; Squamous cell cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms GOBLET

Most Recent Events

  • 14 May 2025 According to an Oncolytics Biotech media release, company anticipates initial efficacy results from Cohort 5 of the GOBLET study investigating pelareorep combined with modified FOLFIRINOX with or without atezolizumab in newly diagnosed metastatic pancreatic cancer in H1 2026:
  • 14 May 2025 According to an Oncolytics Biotech media release, company anticipates pancreatic cancer translational data from Cohort 1 of the GOBLET study evaluating pelareorep, gemcitabine, nab-paclitaxel, and atezolizumab in Q2 2025.
  • 24 Apr 2025 According to an Oncolytics Biotech media release, company will present data from cohort 1 of this study at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in ChicagoMay 30-June 3, 2025.

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