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A Multi-centre Phase II, Double-Blind, Randomised Study of Savolitinib in Combination With Osimertinib vs Savolitinib in Combination With Placebo in Patients With EGFRm+ and MET Amplified Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed Following Treatment With Osimertinib

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Trial Profile

A Multi-centre Phase II, Double-Blind, Randomised Study of Savolitinib in Combination With Osimertinib vs Savolitinib in Combination With Placebo in Patients With EGFRm+ and MET Amplified Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed Following Treatment With Osimertinib

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 06 Jun 2024

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At a glance

  • Drugs Osimertinib (Primary) ; Savolitinib (Primary)
  • Indications Non-small cell lung cancer
  • Focus Therapeutic Use
  • Acronyms CoC
  • Sponsors AstraZeneca
  • Most Recent Events

    • 10 Apr 2024 Results assessing activity of the combination of savolitinib and osimertinib against the combination of savolitinib with placebo to osimertinib in patients with Epidermal Growth Factor Receptor Mutation Positive and MET amplified, locally advanced or metastatic non-small cell lung cancer presented at the 115th Annual Meeting of the American Association for Cancer Research.
    • 10 Apr 2024 Status changed from active, no longer recruiting to discontinued.
    • 05 Apr 2024 According to a HUTCHMED media release, company announces that results from this study will be presented at the upcoming American Association of Cancer Research (AACR) Annual Meeting 2024,on April 5 to 10, 2024 in San Diego, California.
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