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An Open-label, Multicenter, Dose Escalation Phase 1b Study to Assess the Safety and Pharmacokinetics of Subcutaneous Delivery of Amivantamab, a Human Bispecific EGFR and cMet Antibody for the Treatment of Advanced Solid Malignancies

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Trial Profile

An Open-label, Multicenter, Dose Escalation Phase 1b Study to Assess the Safety and Pharmacokinetics of Subcutaneous Delivery of Amivantamab, a Human Bispecific EGFR and cMet Antibody for the Treatment of Advanced Solid Malignancies

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 27 Jun 2025

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At a glance

  • Drugs Amivantamab (Primary) ; Hyaluronidase (Primary) ; Lazertinib (Primary)
  • Indications Advanced breast cancer; Colorectal cancer; Gastric cancer; Head and neck cancer; Liver cancer; Mesothelioma; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Renal cell carcinoma; Solid tumours; Squamous cell cancer; Thyroid cancer
  • Focus Adverse reactions; Pharmacokinetics
  • Acronyms PALOMA
  • Sponsors Janssen Research & Development

Most Recent Events

  • 22 Jun 2025 Planned number of patients changed from 166 to 192.
  • 22 Jun 2025 Planned End Date changed from 21 Oct 2025 to 30 Apr 2027.
  • 22 Jun 2025 Status changed from active, no longer recruiting to recruiting.

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