Trial Profile

A Phase 2 Study of Brentuximab Vedotin in Combination With Pembrolizumab in Subjects With Metastatic Solid Malignancies After Progression on Prior PD-1 Inhibitor Treatment

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 17 Dec 2025

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At a glance

Drugs Brentuximab vedotin (Primary) ; Pembrolizumab (Primary)
Indications Carcinoma; Malignant melanoma; Non-small cell lung cancer; Skin cancer; Squamous cell cancer
Focus Therapeutic Use
Sponsors Seagen

Most Recent Events

10 Nov 2025 Planned End Date changed from 31 Dec 2029 to 31 Dec 2026.
10 Nov 2025 Planned primary completion date changed from 31 Dec 2029 to 31 Dec 2026.
13 May 2025 Planned number of patients changed from 142 to 141.

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