Trial Profile

A PHASE 1/2A DOSE ESCALATION AND EXPANSION STUDY TO EVALUATE SAFETY, TOLERABILITY, PHARMACOKINETIC, PHARMACODYNAMIC, AND ANTI-TUMOR ACTIVITY OF PF-07248144 IN PARTICIPANTS WITH ADVANCED OR METASTATIC SOLID TUMORS

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 11 Jun 2025

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At a glance

Drugs Atirmociclib (Primary) ; Fulvestrant (Primary) ; Letrozole (Primary) ; Palbociclib (Primary) ; PF-07248144 (Primary) ; Vepdegestrant (Primary)
Indications Advanced breast cancer; HER2 negative breast cancer; Non-small cell lung cancer; Prostate cancer; Solid tumours
Focus Adverse reactions; First in man
Acronyms KAT6
Sponsors Pfizer

04 Jun 2025 Study phase changed from phase 1 to phase 1/2. Number of treatment arms have been increased from 8 to 10 by the addition of 2 new vepdegestrant combination experimental arms.
04 Jun 2025 Planned number of patients changed from 186 to 320.
04 Jun 2025 Planned End Date changed from 7 Mar 2027 to 30 Jan 2028.

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