Trial Profile

A Phase 1b, Multicenter, 2-Part, Open-Label Study of Datopotamab Deruxtecan (Dato-DXd) in Combination With Immunotherapy With or Without Carboplatin in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (Tropion-Lung04)

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 04 Aug 2026

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At a glance

Drugs Datopotamab deruxtecan (Primary) ; Durvalumab (Primary) ; Rilvegostomig (Primary) ; Volrustomig (Primary) ; Carboplatin
Indications Non-small cell lung cancer
Focus Adverse reactions; Pharmacogenomic
Acronyms TROPION-Lung04
Sponsors AstraZeneca

27 Jul 2026 Planned End Date changed from 4 May 2026 to 4 May 2027.
06 Apr 2026 Planned End Date changed from 30 Jan 2026 to 4 May 2026.
06 Apr 2026 Planned primary completion date changed from 30 Jan 2026 to 4 May 2026.

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