A Phase 2 Multicenter Study of Autologous Tumor Infiltrating Lymphocytes (TIL or LN-145) in Patients With Metastatic Non-Small-Cell Lung Cancer
Latest Information Update: 13 Aug 2024
At a glance
- Drugs LN 145 (Primary) ; Aldesleukin; Cyclophosphamide; Fludarabine
- Indications Adenocarcinoma; Carcinoma; Non-small cell lung cancer; Squamous cell cancer
- Focus Registrational; Therapeutic Use
- Sponsors Iovance Biotherapeutics
- 08 Aug 2024 According to an Iovance Biotherapeutics media release, company expects to complete enrollment and report topline data from the registrational cohorts in IOV-LUN-202 in 2025 to support a potential supplemental biologics license application for lifileucel in 2026 for potential accelerated approval.
- 09 May 2024 According to an Iovance Biotherapeutics media release, At a recent Type D meeting, the FDA provided positive regulatory feedback on the proposed potency matrix for lifileucel in NSCLC. The FDA previously provided positive regulatory feedback that the design of the single-arm IOV-LUN-202 trial may be acceptable for approval of lifileucel in post-anti-PD-1 NSCLC.
- 08 May 2024 Planned End Date changed from 1 Dec 2026 to 1 Dec 2031.