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An Open-label, Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of MEDI9253, a Recombinant Newcastle Disease Virus Encoding Interleukin-12, in Combination With Durvalumab in Participants With Select Advanced/Metastatic Solid Tumors

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Trial Profile

An Open-label, Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of MEDI9253, a Recombinant Newcastle Disease Virus Encoding Interleukin-12, in Combination With Durvalumab in Participants With Select Advanced/Metastatic Solid Tumors

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 17 Jun 2024

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At a glance

  • Drugs Durvalumab (Primary) ; MEDI 9253 (Primary)
  • Indications Colorectal cancer; Malignant melanoma; Renal cell carcinoma; Solid tumours
  • Focus Adverse reactions; First in man
  • Sponsors AstraZeneca

    • Most Recent Events

    • 13 Jun 2024 Status changed from active, no longer recruiting to completed.
    • 07 Sep 2023 Planned End Date changed from 27 Feb 2025 to 26 Nov 2024.
    • 07 Sep 2023 Planned primary completion date changed from 27 Feb 2025 to 26 Nov 2024.

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