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Phase I Trial of Methotrexate, Rituximab, Lenalidomide, and Nivolumab (Nivo-MR2) Induction Followed by Lenalidomide and Nivolumab Maintenance in Primary CNS Lymphoma

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Trial Profile

Phase I Trial of Methotrexate, Rituximab, Lenalidomide, and Nivolumab (Nivo-MR2) Induction Followed by Lenalidomide and Nivolumab Maintenance in Primary CNS Lymphoma

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 27 Sep 2025

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At a glance

  • Drugs Lenalidomide (Primary) ; Methotrexate (Primary) ; Methotrexate (Primary) ; Nivolumab (Primary) ; Rituximab (Primary)
  • Indications CNS cancer; Diffuse large B cell lymphoma
  • Focus Adverse reactions

Most Recent Events

  • 08 Aug 2025 Planned End Date changed from 31 May 2025 to 31 May 2026.
  • 08 Aug 2025 Planned primary completion date changed from 31 May 2025 to 31 May 2026.
  • 10 Dec 2024 Trial in progress data has been presented at the 66th American Society of Hematology Annual Meeting and Exposition.

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