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A Phase I Study of In Situ Immunomodulation With CDX-301, Radiotherapy, CDX-1140, and Poly-ICLC in Patients With Unresectable and Metastatic Solid Tumors With Injectable Palpable Disease

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Trial Profile

A Phase I Study of In Situ Immunomodulation With CDX-301, Radiotherapy, CDX-1140, and Poly-ICLC in Patients With Unresectable and Metastatic Solid Tumors With Injectable Palpable Disease

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 16 Jul 2025

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At a glance

  • Drugs CDX 1140 (Primary) ; CDX 1140 (Primary) ; CDX 301 (Primary) ; Poly ICLC (Primary)
  • Indications Advanced breast cancer; HER2 negative breast cancer; Male breast cancer; Malignant melanoma; Merkel cell carcinoma; Osteosarcoma; Skin cancer; Soft tissue sarcoma; Squamous cell cancer
  • Focus Adverse reactions

Most Recent Events

  • 16 Dec 2024 Planned End Date changed from 9 Jan 2026 to 9 Jan 2027.
  • 16 Dec 2024 Planned primary completion date changed from 9 Jan 2025 to 9 Jan 2026.
  • 04 Jun 2024 Recruitment is currently 4 on February 6, 2024 as reported in trial design presented at the 60th Annual Meeting of the American Society of Clinical Oncology

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