Trial Profile

A Phase 1b/2 Study of Immune and Targeted Combination Therapies in Participants With RCC (U03): Substudy 03A in First Line Metastatic Participants

Status: Active, no longer recruiting

Phase of Trial: Phase I/II

Latest Information Update: 10 Sep 2026

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At a glance

Drugs Belzutifan (Primary) ; Favezelimab/pembrolizumab (Primary) ; Lenvatinib (Primary) ; Pembrolizumab (Primary) ; Pembrolizumab+vibostolimab (Primary) ; Pembrolizumab/Quavonlimab (Primary)
Indications Renal cell carcinoma
Focus Adverse reactions; Therapeutic Use
Acronyms Substudy 03A
Sponsors Merck Sharp & Dohme Corp.

Most Recent Events

30 Jul 2026 Planned End Date changed from 17 Jul 2026 to 21 Aug 2026.
30 Jul 2026 Planned primary completion date changed from 17 Jul 2026 to 21 Aug 2026.
06 May 2026 Planned End Date changed from 31 May 2026 to 17 Jul 2026.

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