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ENLIGHTEN 1: A Phase III, Randomized, Blinded, Controlled, Parallel-Group Trial to Evaluate the Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis (CRS) in Adults

Trial Profile

ENLIGHTEN 1: A Phase III, Randomized, Blinded, Controlled, Parallel-Group Trial to Evaluate the Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis (CRS) in Adults

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 14 May 2025

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At a glance

  • Drugs Mometasone (Primary)
  • Indications Rhinosinusitis
  • Focus Registrational; Therapeutic Use
  • Acronyms ENLIGHTEN 1
  • Sponsors Lyra Therapeutics

Most Recent Events

  • 07 May 2025 Results presented in a Lyra Therapeutics Media Release.
  • 07 May 2025 According to a Lyra Therapeutics media release, the Company plans to present results from the 52-week Extension Stage of the ENLIGHTEN 1 Phase 3 study at the annual Combined Otolaryngology Spring Meetings (COSM 2025) being held May 14-18 in New Orleans.
  • 06 May 2025 According to a Lyra Therapeutics media release, company expect an additional ~30 polyp patients in the ENLIGHTEN 2 trial, which combined with the 35 polyp patients in the ENLIGHTEN 1 trial, would result in a total of ~65 polyp patients in the ENLIGHTEN program.

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