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A Phase II, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of Trastuzumab Deruxtecan (T-DXd) for the Treatment of Unresectable and/or Metastatic Solid Tumors Harboring HER2 Activating Mutations Regardless of Tumor Histology

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A Phase II, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of Trastuzumab Deruxtecan (T-DXd) for the Treatment of Unresectable and/or Metastatic Solid Tumors Harboring HER2 Activating Mutations Regardless of Tumor Histology

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 02 Sep 2024

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At a glance

  • Drugs Trastuzumab-deruxtecan (Primary)
  • Indications Adenocarcinoma; Solid tumours
  • Focus Therapeutic Use
  • Acronyms DESTINY-PanTumor01; DPT01
  • Sponsors AstraZeneca

    • Most Recent Events

    • 22 Jan 2024 Planned End Date changed from 17 Jan 2028 to 14 Jul 2026.
    • 24 Oct 2023 Results (data cutoff Jan 25 2023) assessing the efficacy and safety of trastuzumab deruxtecan in patients with solid tumors, presented at the 48th European Society for Medical Oncology Congress.
    • 11 Oct 2023 According to an AstraZeneca media release, clinical data from this will be presented at the European Society for Medical Oncology (ESMO) Congress, October 20-24, 2023.

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