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The TRISTARDS Trial - ThRombolysIS Therapy for ARDS A Phase IIb/III Operationally Seamless, Open-label, Randomised, Sequential, Parallel-group Adaptive Study to Evaluate the Efficacy and Safety of Daily Intravenous Alteplase Treatment Given up to 5 Days on Top of Standard of Care (SOC) Compared With SOC Alone, in Patients With Acute Respiratory Distress Syndrome (ARDS) Triggered by COVID-19

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Trial Profile

The TRISTARDS Trial - ThRombolysIS Therapy for ARDS A Phase IIb/III Operationally Seamless, Open-label, Randomised, Sequential, Parallel-group Adaptive Study to Evaluate the Efficacy and Safety of Daily Intravenous Alteplase Treatment Given up to 5 Days on Top of Standard of Care (SOC) Compared With SOC Alone, in Patients With Acute Respiratory Distress Syndrome (ARDS) Triggered by COVID-19

Status: Completed
Phase of Trial: Phase II/III

Latest Information Update: 23 May 2024

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At a glance

  • Drugs Alteplase (Primary)
  • Indications COVID-19 respiratory infection; SARS-CoV-2 acute respiratory disease
  • Focus Registrational; Therapeutic Use
  • Acronyms TRISTARDS
  • Sponsors Boehringer Ingelheim

    • Most Recent Events

    • 11 Feb 2024 This study has been completed in Portugal, according to European Clinical Trials Database record.
    • 31 Jan 2024 This study has been completed in France, according to European Clinical Trials Database record.
    • 15 Oct 2023 The trial has been completed in Spain, according to European Clinical Trials Database record.

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