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A Phase I, Open-label, Fixed-sequence, Crossover, Drug-drug Interaction Study to Investigate the Inhibition Potential of KL1333 on CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 in Healthy Subjects

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Trial Profile

A Phase I, Open-label, Fixed-sequence, Crossover, Drug-drug Interaction Study to Investigate the Inhibition Potential of KL1333 on CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 in Healthy Subjects

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 22 Oct 2021

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At a glance

  • Drugs KL 1333 (Primary) ; Bupropion; Caffeine; Dextromethorphan; Flurbiprofen; Midazolam; Omeprazole; Repaglinide
  • Indications Diabetes mellitus; Mitochondrial disorders
  • Focus Pharmacokinetics; Proof of concept
  • Sponsors Abliva

    • Most Recent Events

    • 19 Oct 2021 Status changed from recruiting to completed.
    • 03 Dec 2020 New trial record
    • 20 Nov 2020 According to an Abliva media release, company doses the first healthy volunteers in the company's drug-drug interaction study (DDI study) with KL1333.

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