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MAGNETISMM-3 AN OPEN-LABEL, MULTICENTER, NON-RANDOMIZED PHASE 2 STUDY OF ELRANATAMAB (PF-06863135) MONOTHERAPY IN PARTICIPANTS WITH MULTIPLE MYELOMA WHO ARE REFRACTORY TO AT LEAST ONE PROTEASOME INHIBITOR, ONE IMMUNOMODULATORY DRUG AND ONE ANTI-CD38 ANTIBODY

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Trial Profile

MAGNETISMM-3 AN OPEN-LABEL, MULTICENTER, NON-RANDOMIZED PHASE 2 STUDY OF ELRANATAMAB (PF-06863135) MONOTHERAPY IN PARTICIPANTS WITH MULTIPLE MYELOMA WHO ARE REFRACTORY TO AT LEAST ONE PROTEASOME INHIBITOR, ONE IMMUNOMODULATORY DRUG AND ONE ANTI-CD38 ANTIBODY

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 20 May 2024

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At a glance

  • Drugs Elranatamab (Primary)
  • Indications Multiple myeloma
  • Focus Registrational; Therapeutic Use
  • Acronyms Elemmental-3; MagnetisMM-3
  • Sponsors Pfizer
  • Most Recent Events

    • 26 Mar 2024 According to a Pfizer media release, based on results from MagnetisMM-3 and MagnetisMM-2 study the company has obtained manufacturing and marketing approval in Japan for Elrefio subcutaneous injection 44mg, 76mg in Japan for patients with relapsed or refractory multiple myeloma.
    • 01 Mar 2024 Planned End Date changed from 6 Apr 2024 to 31 Dec 2025.
    • 13 Feb 2024 According to a Pfizer media release, Health Canada has granted a Notice of Compliance with conditions (NOC/c) to ELREXFIO (elranatamab solution for injection). ELREXFIO is indicated for the treatment of adult patients with relapsed or refractory multiple myeloma (RRMM) who have received at least 3 prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent and an anti-CD38 monoclonal antibody, and who have demonstrated disease progression on the last therapy.
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