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Phase I/II Evaluation of Aerosolized Azacytidine as Epigenetic Priming for Bintrafusp Alfa-Mediated Immune Checkpoint Blockade in Patients With Unresectable Pulmonary Metastases From Sarcomas, Germ Cell Tumors, or Epithelial Malignancies

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Trial Profile

Phase I/II Evaluation of Aerosolized Azacytidine as Epigenetic Priming for Bintrafusp Alfa-Mediated Immune Checkpoint Blockade in Patients With Unresectable Pulmonary Metastases From Sarcomas, Germ Cell Tumors, or Epithelial Malignancies

Status: Withdrawn prior to enrolment
Phase of Trial: Phase I/II

Latest Information Update: 22 Dec 2021

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At a glance

  • Drugs Azacitidine (Primary) ; Bintrafusp alfa (Primary)
  • Indications Cancer metastases; Germ cell and embryonal neoplasms; Germ cell cancer; Lung cancer; Malignant melanoma; Sarcoma
  • Focus Adverse reactions; Pharmacokinetics; Therapeutic Use

    • Most Recent Events

    • 16 Dec 2021 Status changed from suspended to withdrawn prior to enrolment.
    • 08 Nov 2021 Planned primary completion date changed from 30 Dec 2028 to 30 Dec 2029.
    • 20 Oct 2021 Status changed from recruiting to suspended due to pending approval of amendment.

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