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An Open-Label, Multicenter Phase 1b/2 Study of Nanatinostat and Valganciclovir in Patients With Advanced Epstein-Barr Virus-Positive (EBV+) Solid Tumors and in Combination With Pembrolizumab in Patients With Recurrent/Metastatic Nasopharyngeal Carcinoma

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Trial Profile

An Open-Label, Multicenter Phase 1b/2 Study of Nanatinostat and Valganciclovir in Patients With Advanced Epstein-Barr Virus-Positive (EBV+) Solid Tumors and in Combination With Pembrolizumab in Patients With Recurrent/Metastatic Nasopharyngeal Carcinoma

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 22 Jul 2024

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At a glance

  • Drugs Nanatinostat/valganciclovir combination therapy (Primary) ; Pembrolizumab (Primary) ; Valganciclovir (Primary)
  • Indications Carcinoma; Gastric cancer; Leiomyosarcoma; Nasopharyngeal cancer; Solid tumours
  • Focus Adverse reactions; Proof of concept; Therapeutic Use
  • Sponsors Viracta Therapeutics

    • Most Recent Events

    • 07 Mar 2024 According to a Viracta Therapeutics media release, the company expects to determine the recommended Phase 2 dose (RP2D) in the second half of 2024, Initiate a dose-optimization cohort to confirm the RP2D as part of the studys Phase 2 expansion by year-end 2024.
    • 07 Mar 2024 According to a Viracta Therapeutics media release, the company completed enrollment into first split daily dosing cohort of the Phase 1b/2 study of Nana-val in patients with advanced EBV+ solid tumors
    • 29 Feb 2024 According to a Viracta Therapeutics media release, the company look forward to publish data from the Phase 1b/2 clinical trial and reporting topline PTCL cohort data from Stage 1 of the NAVAL-1 trial in the second quarter of 2024.

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