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An Open-Label, Multicenter Phase 1b/2 Study of Nanatinostat and Valganciclovir in Patients with Advanced Epstein-Barr Virus-Positive (EBV+) Solid Tumors and in Combination with Pembrolizumab in Patients with Recurrent/Metastatic Nasopharyngeal Carcinoma

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Trial Profile

An Open-Label, Multicenter Phase 1b/2 Study of Nanatinostat and Valganciclovir in Patients with Advanced Epstein-Barr Virus-Positive (EBV+) Solid Tumors and in Combination with Pembrolizumab in Patients with Recurrent/Metastatic Nasopharyngeal Carcinoma

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 25 Nov 2024

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At a glance

  • Drugs Nanatinostat/valganciclovir combination therapy (Primary) ; Pembrolizumab (Primary) ; Valganciclovir (Primary)
  • Indications Carcinoma; Gastric cancer; Leiomyosarcoma; Nasopharyngeal cancer; Solid tumours
  • Focus Adverse reactions; Proof of concept; Therapeutic Use
  • Sponsors Viracta Therapeutics

    • Most Recent Events

    • 01 Oct 2024 According to a Viracta Therapeutics media release, the company determined the recommended Phase 2 dose in patients with advanced EBV+ solid tumors.
    • 19 Sep 2024 Status changed from recruiting to active, no longer recruiting.
    • 07 Mar 2024 According to a Viracta Therapeutics media release, the company expects to determine the recommended Phase 2 dose (RP2D) in the second half of 2024, Initiate a dose-optimization cohort to confirm the RP2D as part of the studys Phase 2 expansion by year-end 2024.

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