Trial Profile

A Phase 1/2, First-in-Human, Open-Label, Dose Escalation Study of Talquetamab, a Humanized GPRC5D x CD3 Bispecific Antibody, in Subjects With Relapsed or Refractory Multiple Myeloma

Status: Recruiting

Phase of Trial: Phase II

Latest Information Update: 16 Sep 2026

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At a glance

Drugs Talquetamab (Primary) ; Talquetamab (Primary) ; Recombinant human serum albumin
Indications Multiple myeloma
Focus First in man; Registrational; Therapeutic Use
Acronyms MonumenTAL-1
Sponsors Janssen Research & Development; Janssen-Cilag

Most Recent Events

08 May 2026 Planned primary completion date changed from 31 Mar 2026 to 30 Jun 2027.
25 Apr 2025 Planned End Date changed from 31 Mar 2027 to 30 Mar 2029.
18 Mar 2025 Planned number of patients changed from 480 to 510.

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