Trial Profile

A Phase I/IIa, Open-label, Multi-center Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of the ATR Kinase Inhibitor ART0380 Administered Orally as Monotherapy and in Combination to Patients With Advanced or Metastatic Solid Tumors

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 07 Aug 2026

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At a glance

Drugs Alnodesertib (Primary) ; Gemcitabine (Primary) ; Irinotecan (Primary)
Indications Adenocarcinoma; Anal cancer; Carcinoma; Cholangiocarcinoma; Colorectal cancer; Endometrial cancer; Fallopian tube cancer; Ovarian cancer; Pancreatic ductal carcinoma; Peritoneal cancer; Solid tumours
Focus Adverse reactions; First in man; Proof of concept; Therapeutic Use
Acronyms STELLA
Sponsors Artios Pharma

30 Jul 2026 Planned number of patients changed from 442 to 542.
30 Jul 2026 Planned End Date changed from 1 Dec 2027 to 1 Jun 2028.
30 Jul 2026 Planned primary completion date changed from 1 Dec 2026 to 1 Jan 2028.

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