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A Phase 3 Open-Label, Randomized Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN-CLL-314)

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Trial Profile

A Phase 3 Open-Label, Randomized Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN-CLL-314)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 17 Jun 2025

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At a glance

  • Drugs Pirtobrutinib (Primary) ; Ibrutinib
  • Indications Chronic lymphocytic leukaemia
  • Focus Expanded access; Therapeutic Use
  • Acronyms BRUIN-CLL-314
  • Sponsors Loxo Oncology

Most Recent Events

  • 11 Jun 2025 Planned number of patients changed from 650 to 725.
  • 31 Jan 2025 Planned End Date changed from 1 Aug 2028 to 1 Jan 2028.
  • 31 Jan 2025 Planned primary completion date changed from 1 Feb 2025 to 1 Jun 2025.

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