Trial Profile

A PHASE 3, RANDOMIZED, DOUBLE-BLIND STUDY OF ENCORAFENIB AND BINIMETINIB PLUS PEMBROLIZUMAB VERSUS PLACEBO PLUS PEMBROLIZUMAB IN PARTICIPANTS WITH BRAF V600E/K MUTATION-POSITIVE METASTATIC OR UNRESECTABLE LOCALLY ADVANCED MELANOMA

Status: Active, no longer recruiting

Phase of Trial: Phase III

Latest Information Update: 17 Mar 2026

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At a glance

Drugs Binimetinib (Primary) ; Encorafenib (Primary) ; Pembrolizumab (Primary)
Indications Malignant melanoma; Skin cancer
Focus Adverse reactions; Registrational; Therapeutic Use
Acronyms STARBOARD
Sponsors Pfizer

02 Mar 2026 Planned End Date changed from 23 Mar 2026 to 31 Aug 2026.
14 Aug 2025 Planned End Date changed from 30 Dec 2025 to 23 Mar 2026.
14 Aug 2025 Planned primary completion date changed from 22 Sep 2025 to 14 Dec 2025.

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