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A Phase 1b/2a Basket Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Combination Therapy With the Anti CD19 Monoclonal Antibody Tafasitamab and the PI3Kδ Inhibitor Parsaclisib in Adult Participants With Relapsed/Refractory Non Hodgkin Lymphoma or Chronic Lymphocytic Leukemia

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Trial Profile

A Phase 1b/2a Basket Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Combination Therapy With the Anti CD19 Monoclonal Antibody Tafasitamab and the PI3Kδ Inhibitor Parsaclisib in Adult Participants With Relapsed/Refractory Non Hodgkin Lymphoma or Chronic Lymphocytic Leukemia

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 02 Feb 2026

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At a glance

  • Drugs Parsaclisib (Primary) ; Tafasitamab (Primary)
  • Indications Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma
  • Focus Adverse reactions; Proof of concept
  • Acronyms topMIND
  • Sponsors Incyte Corporation

Most Recent Events

  • 29 Jan 2026 Status changed from completed to discontinued. ( A business decision was made to discontinue further enrollment. There were no safety concerns that contributed to this decision. )
  • 18 Nov 2024 Status changed from active, no longer recruiting to completed.
  • 18 Dec 2023 Planned End Date changed from 31 Oct 2023 to 15 Dec 2024.

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