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A Phase 1, Multicenter, Open-Label, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, PK/PD, and Clinical Activity of Intravenously Administered KT-413 in Adult Patients With Relapsed or Refractory B-cell NHL

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Trial Profile

A Phase 1, Multicenter, Open-Label, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, PK/PD, and Clinical Activity of Intravenously Administered KT-413 in Adult Patients With Relapsed or Refractory B-cell NHL

Status: Suspended
Phase of Trial: Phase I

Latest Information Update: 27 Nov 2023

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At a glance

  • Drugs KT 413 (Primary)
  • Indications B-cell lymphoma; Diffuse large B cell lymphoma; Follicular lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; Plasmablastic lymphoma
  • Focus Adverse reactions; Proof of concept
  • Sponsors Kymera Therapeutics
  • Most Recent Events

    • 17 Nov 2023 Status changed from recruiting to suspended as per sponsor decision.
    • 14 Jun 2023 Results (n=5; As of the data cut-off of June 1, 2023, DL1-3 have been completed and DL4 remains open to accrual) presented in a Kymera Therapeutics media release.
    • 14 Jun 2023 According to a Kymera Therapeutics media release, company shared new data demonstrating that KT-413, continue to demonstrate robust dose-dependent target knockdown in ongoing Phase 1a dose escalation clinical trials, with no dose limiting toxicities observed.

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