A Phase 1, Multicenter, Open-Label, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, PK/PD, and Clinical Activity of Intravenously Administered KT-413 in Adult Patients With Relapsed or Refractory B-cell NHL
Latest Information Update: 27 Nov 2023
At a glance
- Drugs KT 413 (Primary)
- Indications B-cell lymphoma; Diffuse large B cell lymphoma; Follicular lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; Plasmablastic lymphoma
- Focus Adverse reactions; Proof of concept
- Sponsors Kymera Therapeutics
- 17 Nov 2023 Status changed from recruiting to suspended as per sponsor decision.
- 14 Jun 2023 Results (n=5; As of the data cut-off of June 1, 2023, DL1-3 have been completed and DL4 remains open to accrual) presented in a Kymera Therapeutics media release.
- 14 Jun 2023 According to a Kymera Therapeutics media release, company shared new data demonstrating that KT-413, continue to demonstrate robust dose-dependent target knockdown in ongoing Phase 1a dose escalation clinical trials, with no dose limiting toxicities observed.