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Vitrectomy, Subretinal Tissue Plasminogen Activator and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative Age-Related Macular Degeneration (TIGER): a Phase 3, Pan-European, Two-group, Observer-masked, Superiority, Randomised Controlled Surgical Trial

Trial Profile

Vitrectomy, Subretinal Tissue Plasminogen Activator and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative Age-Related Macular Degeneration (TIGER): a Phase 3, Pan-European, Two-group, Observer-masked, Superiority, Randomised Controlled Surgical Trial

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 20 May 2025

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At a glance

  • Drugs Aflibercept (Primary) ; Alteplase; Sulfur hexafluoride
  • Indications Haemorrhage; Wet age-related macular degeneration
  • Focus Therapeutic Use
  • Acronyms TIGER

Most Recent Events

  • 14 Apr 2025 Protocol amendments updates including 1.Addition of other brand of medication Alteplase, 2.Baseline treatments for participants in control group, 3.Secondary outcome measure,and 4.Treatment Additional injections of aflibercept. has been published in the Trials.
  • 14 Apr 2025 Protocol amendment updates from this trial were published in the Trials.
  • 31 Jan 2022 Status changed from not yet recruiting to recruiting.

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