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Safety, Tolerability and Efficacy of Regorafenib in Combination With FOLFIRINOX in Patients With RAS-mutated Metastatic Colorectal Cancer: a Dose-escalation, Phase I/II Trial

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Trial Profile

Safety, Tolerability and Efficacy of Regorafenib in Combination With FOLFIRINOX in Patients With RAS-mutated Metastatic Colorectal Cancer: a Dose-escalation, Phase I/II Trial

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 21 Jan 2025

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At a glance

  • Drugs Fluorouracil (Primary) ; Irinotecan (Primary) ; Levofolinic acid (Primary) ; Oxaliplatin (Primary) ; Regorafenib (Primary)
  • Indications Colorectal cancer
  • Focus Adverse reactions; First in man
  • Acronyms FOLFIRINOX-R

Most Recent Events

  • 15 Jan 2025 Status changed from active, no longer recruiting to completed.
  • 01 Sep 2024 Results assessing safety published in the Cancer Chemotherapy and Pharmacology
  • 08 Feb 2024 Planned End Date changed from 31 Oct 2024 to 30 Nov 2024.

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