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A multicenter, randomized, double-blind, placebo-controlled, phase 2, 12-week treatment study followed by a 12 week open label phase and a 12-week follow-up period to assess the efficacy and safety of avdoralimab (IPH5401) C5aR blocking antibody in adult patients with chronic spontaneous urticaria resistant to H1-antihistamine treatment.

Trial Profile

A multicenter, randomized, double-blind, placebo-controlled, phase 2, 12-week treatment study followed by a 12 week open label phase and a 12-week follow-up period to assess the efficacy and safety of avdoralimab (IPH5401) C5aR blocking antibody in adult patients with chronic spontaneous urticaria resistant to H1-antihistamine treatment.

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 01 Apr 2022

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At a glance

  • Drugs Avdoralimab (Primary)
  • Indications Urticaria
  • Focus Therapeutic Use
  • Acronyms CRUSE

Most Recent Events

  • 01 Apr 2022 Status changed from recruiting to discontinued.
  • 05 Jan 2021 New trial record

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