Trial Profile

A Phase Ib/II Open-label, Multi-center Dose Escalation Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

Status: Active, no longer recruiting

Phase of Trial: Phase I/II

Latest Information Update: 12 Mar 2025

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At a glance

Drugs Batoprotafib (Primary) ; Opnurasib (Primary) ; Tislelizumab (Primary)
Indications Biliary cancer; Carcinoma; Colorectal cancer; Duodenal neoplasms; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Solid tumours
Focus Adverse reactions; First in man; Therapeutic Use
Acronyms KontRASt-01
Sponsors Novartis Pharma A.G.; Novartis Pharmaceuticals

Most Recent Events

10 Mar 2025 Planned End Date changed from 30 Apr 2026 to 26 Aug 2026.
10 Mar 2025 Planned primary completion date changed from 30 Apr 2026 to 26 Aug 2026.
17 Dec 2024 Planned End Date changed from 5 Aug 2025 to 30 Apr 2026.

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