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A Multi-Center, Open Label, Uncontrolled, Phase 2a Clinical Trial Evaluating the Safety and Efficacy of the Addition of Ibrutinib to Venetoclax Through a MRD-guided Approach in Relapsed/Refractory Patients With Chronic Lymphocytic Leukemia (CLL)

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Trial Profile

A Multi-Center, Open Label, Uncontrolled, Phase 2a Clinical Trial Evaluating the Safety and Efficacy of the Addition of Ibrutinib to Venetoclax Through a MRD-guided Approach in Relapsed/Refractory Patients With Chronic Lymphocytic Leukemia (CLL)

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 06 Oct 2023

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At a glance

  • Drugs Ibrutinib (Primary) ; Venetoclax (Primary)
  • Indications Chronic lymphocytic leukaemia
  • Focus Therapeutic Use
  • Acronyms IMPROVE
  • Most Recent Events

    • 01 Oct 2023 Planned End Date changed from 1 Sep 2023 to 1 Sep 2025.
    • 15 Jun 2023 According to Results presented at the 28th Congress of the European Haematology Association, updated results with longer follow-up will be presented at the meeting.
    • 15 Jun 2023 Results reporting safety and efficacy at a median follow-up of 54 months presented at the 28th Congress of the European Haematology Association

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