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Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid Malignancies

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Trial Profile

Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid Malignancies

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 10 Feb 2026

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At a glance

  • Drugs Antineoplastics (Primary) ; Hafnium oxide (Primary) ; Ipilimumab (Primary) ; Nivolumab (Primary)
  • Indications Cancer metastases; Liver cancer; Liver metastases; Lung cancer; Oesophageal cancer; Solid tumours
  • Focus Adverse reactions; Therapeutic Use

Most Recent Events

  • 06 Feb 2026 Planned End Date changed from 1 Feb 2026 to 1 Feb 2028.
  • 06 Feb 2026 Planned primary completion date changed from 1 Feb 2026 to 1 Feb 2028.
  • 12 Nov 2024 According to a Nanobiotix media release, initial phase 1/2 data for NBTXR3 in combination with an immunotherapy in patients with esophageal cancer expected in 2025.

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