Trial Profile

Phase I/II Study of Stereotactic Radiosurgery With Concurrent Administration of DNA Damage Response (DDR) Inhibitor (OLAparib) Followed by Adjuvant Combination of DuRvalumab (MEDI4736) and Physician's Choice Systemic Therapy in Subjects With BreAst Cancer Brain Metastases

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 14 Jan 2026

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At a glance

Drugs Durvalumab (Primary) ; Olaparib (Primary) ; Capecitabine; Carboplatin; Cisplatin; Eribulin; Gemcitabine; Paclitaxel
Indications Advanced breast cancer; Brain metastases; HER2 negative breast cancer; Male breast cancer; Triple negative breast cancer
Focus Adverse reactions; Therapeutic Use
Acronyms SOLARA

23 Dec 2025 Planned primary completion date changed from 1 Nov 2025 to 1 Feb 2026.
11 Oct 2024 Planned End Date changed from 1 Sep 2026 to 1 Nov 2026.
11 Oct 2024 Planned primary completion date changed from 1 Sep 2024 to 1 Nov 2025.

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