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Phase 1/2 Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of OTX-2002 as a Single Agent and in Combination With Standard of Care in Patients With Hepatocellular Carcinoma and Other Solid Tumor Types Known for Association With the MYC Oncogene

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Trial Profile

Phase 1/2 Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of OTX-2002 as a Single Agent and in Combination With Standard of Care in Patients With Hepatocellular Carcinoma and Other Solid Tumor Types Known for Association With the MYC Oncogene

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 22 Dec 2023

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At a glance

  • Drugs OTX-2002 (Primary) ; Immune checkpoint protein inhibitors; Protein tyrosine kinase inhibitors
  • Indications Liver cancer; Solid tumours
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms MYCHELANGELO I
  • Sponsors Omega Therapeutics
  • Most Recent Events

    • 26 Sep 2023 According to an Omega Therapeutics media release, based on preliminary clinical data of this trial , OTX-2002 continues to advance in monotherapy dose escalation. Following the identification of a recommended dose, the Company expects to initiate expansion cohorts in monotherapy and in combination with standard of care therapies.
    • 26 Sep 2023 Preliminary clinical data of this trial presented in an Omega Therapeutics media release.
    • 25 Sep 2023 According to an Omega Therapeutics media release, company will host a conference call and webcast to discuss preliminary clinical data from the ongoing Phase 1/2 MYCHELANGELO™ I trial of OTX-2002 on Tuesday, September 26, 2023, at 8:00 a.m. ET.
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