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A Phase I Study of HERV-E TCR Transduced Autologous T Cells in Patients With Metastatic Clear Cell Renal Cell Carcinoma

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A Phase I Study of HERV-E TCR Transduced Autologous T Cells in Patients With Metastatic Clear Cell Renal Cell Carcinoma

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 06 Dec 2024

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At a glance

  • Drugs 800 TCR (Primary) ; Cyclophosphamide; Fludarabine
  • Indications Renal cell carcinoma
  • Focus Adverse reactions; First in man

    • Most Recent Events

    • 03 Dec 2024 Number of treatment arms have been increased from 1 to 4 by the addition of separate arms for separate dose levels.
    • 03 Dec 2024 Planned End Date changed from 31 Dec 2032 to 3 Mar 2026.
    • 27 Jan 2024 Results (n=19) investigating T cells transduced with a TCR targeting HERV-E (HERV-E T cells) for the treatment of mccRCC presented at the 2024 Genitourinary Cancers Symposium

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