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A 52-week, Randomised, Double-blind, Placebo-controlled, Parallel-group, Multi-centre Study of the Efficacy and Safety of GSK3511294 Adjunctive Therapy in Adult and Adolescent Participants With Severe Uncontrolled Asthma With an Eosinophilic Phenotype

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Trial Profile

A 52-week, Randomised, Double-blind, Placebo-controlled, Parallel-group, Multi-centre Study of the Efficacy and Safety of GSK3511294 Adjunctive Therapy in Adult and Adolescent Participants With Severe Uncontrolled Asthma With an Eosinophilic Phenotype

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 15 Apr 2026

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At a glance

  • Drugs Depemokimab (Primary)
  • Indications Asthma
  • Focus Registrational; Therapeutic Use
  • Acronyms SWIFT-2
  • Sponsors GlaxoSmithKline; GlaxoSmithKline Research & Development; GSK

Most Recent Events

  • 30 Mar 2026 Results presented in the GSK media release.
  • 30 Mar 2026 According to GSK media release, based on data from SWIFT-1 and SWIFT-2 trials, China's National Medical Products Administration (NMPA) has approved Exdensur (depemokimab) as add-on maintenance treatment of severe asthma characterised by an eosinophilic phenotype in adult and paediatric patients aged 12 years and older.
  • 17 Feb 2026 According to GSK media release, based on data from SWIFT-1 and 2 and ANCHOR-1 and 2 trials, the European Commission has approved Exdensur (depemokimab) for severe asthma and chronic rhinosinusitis with nasal polyps.

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