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A Phase 1 Trial to Evaluate the Safety, Immunogenicity, and Reactogenicity of Heterologous and Homologous Chimpanzee Adenovirus and Self-Amplifying mRNA Prime-Boost Prophylactic Vaccines Against SARS-CoV-2 in Healthy Adults

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Trial Profile

A Phase 1 Trial to Evaluate the Safety, Immunogenicity, and Reactogenicity of Heterologous and Homologous Chimpanzee Adenovirus and Self-Amplifying mRNA Prime-Boost Prophylactic Vaccines Against SARS-CoV-2 in Healthy Adults

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 25 Oct 2023

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At a glance

  • Drugs ChAdV68 S (Primary) ; ChAdV68 S TCE (Primary) ; SAM LNP S (Primary) ; SAM LNP S TCE (Primary)
  • Indications COVID 2019 infections
  • Focus Adverse reactions; Proof of concept
  • Acronyms CORAL-NIH
  • Most Recent Events

    • 19 Oct 2023 Status changed from active, no longer recruiting to completed.
    • 11 Oct 2023 Results published in the Gritstone Oncology Media Release
    • 04 Oct 2023 According to a Gritstone bio media release, data from this study will be presented at the IDWeek 2023, occurring October 11-15, 2023, in Boston, MA.

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