Trial Profile

Combinations of Sacituzumab Govitecan Plus Enfortumab Vedotin and Pembrolizumab for Metastatic Urothelial Carcinoma: the Double Antibody Drug Conjugate (DAD) and Double Antibody Drug Conjugate With Immunotherapy (DAD-IO) Phase I/II Trial

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 09 Feb 2026

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At a glance

Drugs Enfortumab vedotin (Primary) ; Pembrolizumab (Primary) ; Sacituzumab govitecan (Primary)
Indications Bladder cancer; Carcinoma; Pelvic cancer; Renal cancer; Ureteral neoplasms; Urethral cancer; Urogenital cancer
Focus Adverse reactions; Biomarker; Therapeutic Use
Acronyms DAD-IO

23 Jan 2026 According to a 4D Path media release, company has announced its participation as an exploratory biomarker collaborator in the Phase II DAD-IO clinical study to Advance Predictive Biomarkers in Bladder Cancer.
04 Nov 2025 Planned End Date changed from 1 May 2026 to 1 May 2028.
04 Nov 2025 Planned primary completion date changed from 1 Oct 2025 to 1 Feb 2027.

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