Trial Profile

Combinations of Sacituzumab Govitecan Plus Enfortumab Vedotin and Pembrolizumab for Metastatic Urothelial Carcinoma: the Double Antibody Drug Conjugate (DAD) and Double Antibody Drug Conjugate With Immunotherapy (DAD-IO) Phase I/II Trial

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 09 Jun 2025

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At a glance

Drugs Enfortumab vedotin (Primary) ; Pembrolizumab (Primary) ; Sacituzumab govitecan (Primary)
Indications Bladder cancer; Carcinoma; Pelvic cancer; Renal cancer; Ureteral neoplasms; Urethral cancer; Urogenital cancer
Focus Adverse reactions; Therapeutic Use

03 Jun 2025 The protocol has been amended to change in study phase with addition in treatment arm and some primary therapeutic endpoints.
03 Jun 2025 Planned number of patients changed from 24 to 106.
03 Jun 2025 Status changed from active, no longer recruiting to recruiting.

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