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A Phase 2, Multicenter, Randomized Study to Compare the Efficacy and Safety of MK-7684A or MK-7684A Plus Docetaxel Versus Docetaxel Monotherapy in the Treatment of Participants With Metastatic Non-small Cell Lung Cancer With Progressive Disease After Treatment With a Platinum Doublet Chemotherapy and Immunotherapy

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Trial Profile

A Phase 2, Multicenter, Randomized Study to Compare the Efficacy and Safety of MK-7684A or MK-7684A Plus Docetaxel Versus Docetaxel Monotherapy in the Treatment of Participants With Metastatic Non-small Cell Lung Cancer With Progressive Disease After Treatment With a Platinum Doublet Chemotherapy and Immunotherapy

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 21 May 2024

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At a glance

  • Drugs Pembrolizumab+vibostolimab (Primary) ; Docetaxel
  • Indications Non-small cell lung cancer
  • Focus Therapeutic Use
  • Acronyms KEYVIBE-002
  • Sponsors Merck Sharp & Dohme Corp.
  • Most Recent Events

    • 07 Dec 2023 Primary endpoint has not been met. (Progression Free Survival (PFS) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1) by Blinded Independent Central Review (BICR) Assessment), according to a Merck media release.
    • 07 Dec 2023 According to Merck media release, full results from this trial presented at the 2023 European Society of Medical Oncology (ESMO) Immuno-Oncology (I-O) Annual Congress.
    • 07 Dec 2023 Results published in the Merck & Co Media Release.

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