Trial Profile

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study: 5 Independent Sub-studies of Setmelanotide in Patients With POMC, PCSK1, LEPR, SRC1, SH2B1, or PCSK1 N221D Gene Defects in the Melanocortin-4 Receptor Pathway

Status: Active, no longer recruiting

Phase of Trial: Phase III

Latest Information Update: 10 Mar 2026

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At a glance

26 Feb 2026 According to Rhythm media release, the company is On track to report topline data from Phase 3 EMANATE trial evaluating setmelanotide in rare genetically caused melanocortin-4 receptor (MC4R) pathway diseases in March 2026.
07 May 2025 According to Rhythm media release, the company plans to announce topline data in the Phase 3 EMANATE trial evaluating setmelanotide in genetically caused MC4R pathway diseases in the first quarter of 2026.
26 Feb 2025 According to Rhythm media release, top line data expected first half of 2026.

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