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A Phase 1/2 Study of the Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor NVL-655 in Patients With Advanced NSCLC and Other Solid Tumors (ALKOVE-1)

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Trial Profile

A Phase 1/2 Study of the Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor NVL-655 in Patients With Advanced NSCLC and Other Solid Tumors (ALKOVE-1)

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 28 Sep 2024

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At a glance

  • Drugs NVL 655 (Primary)
  • Indications Advanced breast cancer; Anaplastic large cell lymphoma; Carcinoma; Cholangiocarcinoma; Colorectal cancer; Diffuse large B cell lymphoma; Male breast cancer; Neuroblastoma; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Renal cell carcinoma; Solid tumours; Squamous cell cancer; Thyroid cancer
  • Focus Adverse reactions; First in man; Pharmacodynamics; Pharmacokinetics; Proof of concept; Therapeutic Use
  • Acronyms ALKOVE-1
  • Sponsors Nuvalent

    • Most Recent Events

    • 14 Sep 2024 According to a Nuvalent media release, the company expects to report pivotal data from this trial in 2025.
    • 14 Sep 2024 According to a Nuvalent media release, data from this study were presented at the European Society for Medical Oncology (ESMO) Congress 2024 in Barcelona, Spain.
    • 14 Sep 2024 Results presented in a Nuvalent Media Release.

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