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The effect of semaglutide in subjects with non-cirrhotic non-alcoholic steatohepatitis

Trial Profile

The effect of semaglutide in subjects with non-cirrhotic non-alcoholic steatohepatitis

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 06 Sep 2026

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At a glance

  • Drugs Semaglutide (Primary)
  • Indications Hepatic fibrosis; Non-alcoholic steatohepatitis
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms ESSENCE
  • Sponsors Novo Nordisk

Most Recent Events

  • 19 May 2026 According to a Novo Nordisk media release, data from this study will be presented at the European Association for the Study of the Liver (EASL) Annual Congress 2026 on 27-30 May in Barcelona, Spain.
  • 19 May 2026 Results presented in a Novo Nordisk Media Release.
  • 15 Dec 2025 According to a Novo Nordisk media release, based on results from this trial the Health Canada has issued marketing authorization with conditions [Notice of Compliance with Conditions (NOC/c)] for Wegovy (semaglutide injection) for the treatment of non-cirrhotic metabolic dysfunction-associated steatohepatitis (MASH) in adults with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis).

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