Trial Profile

A Phase 2, Multicenter, Randomized, Study of Trastuzumab Deruxtecan in Participants With HER2-overexpressing Locally Advanced, Unresectable or Metastatic Colorectal Cancer (DESTINY-CRC02)

Status: Completed

Phase of Trial: Phase II

Latest Information Update: 11 Jun 2026

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At a glance

22 May 2026 Results presented in the AstraZeneca media release.
22 May 2026 According to AstraZeneca media release, based on DESTINY-PanTumor02, DESTINY-Lung01 and DESTINY-CRC02 trials data, Enhertu (trastuzumab deruxtecan) has been recommended for approval in the European Union (EU) as a monotherapy for the treatment of adult patients with unresectable or metastatic HER2-positive solid tumours who have received prior treatment and who have no satisfactory treatment options.
23 Mar 2026 According to Daiichi Sankyo Media release, ENHERTU (trastuzumab deruxtecan) has been approved in Japan by Japans Ministry of Health, Labour and Welfare (MHLW).

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