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Efficacy and Safety of Neoadjuvant Immunotherapy and Chemotherapy for Locally Advanced Esophagogastric Junction and Gastric Cancer : a Open-label, Phase 2 Randomised Controlled Trial (NICE Trial)

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Trial Profile

Efficacy and Safety of Neoadjuvant Immunotherapy and Chemotherapy for Locally Advanced Esophagogastric Junction and Gastric Cancer : a Open-label, Phase 2 Randomised Controlled Trial (NICE Trial)

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 26 Feb 2024

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At a glance

  • Drugs Capecitabine (Primary) ; Gimeracil/oteracil/tegafur (Primary) ; Oxaliplatin (Primary) ; Toripalimab (Primary)
  • Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer
  • Focus Therapeutic Use
  • Acronyms NICE

    • Most Recent Events

    • 20 Jan 2024 Results from the cohort C presented at the 2024 Gastrointestinal Cancers Symposium.
    • 09 Nov 2022 Number of arms changed from 2 to 3. Exploratory group arm added to study protocol. Masking changed from open label to double-blind. Planned number of patients also increased.
    • 09 Nov 2022 Planned number of patients changed from 80 to 110.

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