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A Phase 3, Randomized, Double-Blind Study of Ociperlimab, an Anti-TIGIT Antibody, in Combination With Tislelizumab Compared to Pembrolizumab in Patients With Previously Untreated, PD-L1-Selected, and Locally Advanced, Unresectable, or Metastatic Non-Small Cell Lung Cancer

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Trial Profile

A Phase 3, Randomized, Double-Blind Study of Ociperlimab, an Anti-TIGIT Antibody, in Combination With Tislelizumab Compared to Pembrolizumab in Patients With Previously Untreated, PD-L1-Selected, and Locally Advanced, Unresectable, or Metastatic Non-Small Cell Lung Cancer

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 07 Aug 2026

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At a glance

  • Drugs Ociperlimab (Primary) ; Tislelizumab (Primary) ; Pembrolizumab
  • Indications Non-small cell lung cancer; Squamous cell cancer
  • Focus Adverse reactions; Pharmacokinetics; Registrational; Therapeutic Use
  • Acronyms AdvanTIG-302
  • Sponsors BeOne Medicines

Most Recent Events

  • 12 May 2026 Arms increased from 3 to 4. Experimental: Safety Run-In Substudy added newly to study intervention. Safety Run-In Substudy: Number of Participants Experiencing Adverse Events (AEs) and Safety Run-In Substudy: Serum Concentration of Ociperlimab primary endpoints added newly.
  • 12 May 2026 Status changed from active, no longer recruiting to discontinued.
  • 24 Jun 2025 Status changed from discontinued to active, no longer recruiting.

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