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A Phase I/II Study of the Cyclin-Dependent Kinase(CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type 1 (NF1) Related Atypical Neurofibromas

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Trial Profile

A Phase I/II Study of the Cyclin-Dependent Kinase(CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type 1 (NF1) Related Atypical Neurofibromas

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 16 Jun 2025

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At a glance

  • Drugs Abemaciclib (Primary)
  • Indications Neurofibroma; Neurofibromatosis 1; Plexiform neurofibroma
  • Focus Adverse reactions

Most Recent Events

  • 14 Nov 2024 Planned End Date changed from 1 Dec 2026 to 31 Dec 2029.
  • 14 Nov 2024 Planned primary completion date changed from 1 Dec 2025 to 31 Dec 2028.
  • 17 Apr 2024 Planned number of patients changed from 50 to 55.

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