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An Open Label, Multicentre, Phase I Study to Evaluate the Impact of Moderate and Severe Hepatic Impairments on the Pharmacokinetics and Safety of Encorafenib in Combination With Binimetinib in Adult Patients With Unresectable or Metastatic BRAF V600-mutant Solid Tumors

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Trial Profile

An Open Label, Multicentre, Phase I Study to Evaluate the Impact of Moderate and Severe Hepatic Impairments on the Pharmacokinetics and Safety of Encorafenib in Combination With Binimetinib in Adult Patients With Unresectable or Metastatic BRAF V600-mutant Solid Tumors

Status: Withdrawn prior to enrolment
Phase of Trial: Phase I

Latest Information Update: 24 Feb 2023

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At a glance

  • Drugs Binimetinib (Primary) ; Encorafenib (Primary)
  • Indications Malignant melanoma
  • Focus Pharmacokinetics
  • Sponsors Pierre Fabre

    • Most Recent Events

    • 17 Feb 2023 Status changed from not yet recruiting to withdrawn prior to enrolment.
    • 17 Feb 2023 Planned End Date changed from 1 Apr 2024 to 1 May 2023.
    • 17 Feb 2023 Planned primary completion date changed from 1 Mar 2024 to 1 May 2023.

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