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A phase 1/2 study to evaluate the safety, tolerability, and preliminary efficacy of combining pimasertib with DAY101 in patients ≥12 years of age with recurrent, progressive, or refractory solid tumors with MAPK pathway aberrations

Trial Profile

A phase 1/2 study to evaluate the safety, tolerability, and preliminary efficacy of combining pimasertib with DAY101 in patients ≥12 years of age with recurrent, progressive, or refractory solid tumors with MAPK pathway aberrations

Status: Planning
Phase of Trial: Phase I/II

Latest Information Update: 06 Dec 2021

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At a glance

  • Drugs Pimasertib (Primary) ; Tovorafenib (Primary)
  • Indications Solid tumours
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Day One Biopharmaceuticals

Most Recent Events

  • 22 Nov 2021 According to a Day One Biopharmaceuticals media release, company expects to initiate a Phase 1b combination portion of the study with pimasertib, in the first quarter of 2022.
  • 25 Feb 2021 New trial record
  • 23 Feb 2021 According to a Day One Biopharmaceuticals media release, the company has collaborated with the Merck KGaA for the combination study. The company looks forward to initiate this study later in this year 2021.

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